[FUNDED] CIRCULAR: Co-creation and animal-free solutions for atrial fibrillation

A multidisciplinary and multisectoral consortium led by Prof. Bianca Brundel (Amsterdam UMC) acquired funding to study the mechanisms that drive atrial fibrillation, the most common form of cardiac arrhythmia. CIRCULAR was funded by the competitive Dutch NWA-ORC programme. Fundament supported the consortium in all steps of the process, from drafting a convincing pre-proposal and full proposal to writing the rebuttal to reviewers’ comments and preparing for the interview.

CIRCULAR logo by Sketch University

Funding programme: NWA-ORC, Dutch Science Agenda
Duration: sept 2022 – sept 2027
Total budget: 5,1 M€
Consortium: 8 researchers, 10 co-funders and 9 stakeholder organisations
Coordinator: AmsterdamUMC

Showcase of a successful project

The CIRCULAR consortium brings together researchers from different disciplines with patients, healthcare providers, SMEs, larger companies, and citizen scientists. Together, they aim to pilot a novel research approach for atrial fibrillation that is focused on co-creation with patients. Using citizen science, patients already identified five leading triggers to this cardiac disease, which will be further explored in this project. Strong collaboration across the knowledge chain is key to the project.

The NWA-ORC programme aims to facilitate research leading to scientific as well as societal breakthroughs. In CIRCULAR, scientific breakthroughs are foreseen in disentangling the underlying mechanisms leading to atrial fibrillation. In addition, a molecular human atrial fibrillation atlas will be built, serving new high-throughput drug discovery and biomarker research. Societal breakthroughs are foreseen in the development of novel therapies, and mainly to follow up on the treasure of insights atrial fibrillation patients have to offer on their disease. Importantly, the project will solely utilise, and advance, animal-free model systems.

Prof. Brundel acquired a ZonMw ‘Stimuleringssubsidie proefdiervrije innovaties’ of the module knowledge infrastructure for hiring us to provide a full support trajectory in proposal development.

What Bianca says about our support:

“When reading the project proposal after submission I felt so proud of what we had achieved. The project’s storylines perfectly came together and without the support of Fundament I would never have been able to deliver such a comprehensive proposal. This was really great teamwork!”

Read more about our support in preparing strong proposals.

Author: Linde van Ittersum

Co-founder and Research Funding Professional at Fundament.

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